While latex and vinyl gloves have good resistance to a wide variety of alkalis and acids, they are permeable to oils and many solvents. Nitrile gloves, on the other hand, offer optimal protection against many chemicals and oils. The penetration time also depends on the so-called wall thickness, which can vary from manufacturer to manufacturer. Wearers with a latex allergy prefer the more compatible nitrile gloves, which are more comfortable to wear.